Influence of anatomic origin on intracranial distribution of micro-emboli in the baboon.
- 1 November 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 17 (6) , 1198-1202
- https://doi.org/10.1161/01.str.17.6.1198
Abstract
The purpose of this study was to investigate whether the anatomic origin of micro-emboli influences their intracranial distribution. In twenty-two baboons, we examined the distribution of 99-Technetium labelled albumin aggregates (5 to 40 microns in size) after injection into the circulation at the left atrium (LA), carotid trifurcation (CA), and anterior and posterior common carotid artery (CCI). In a further subgroup, the emboli were introduced at the carotid trifurcation with the contralateral carotid artery ligated (CA + L). The results of this study demonstrated that aggregates introduced at the carotid artery lodged preferentially in the ophthalmic (p = 0.032) and middle cerebral artery territories (p = 0.016). If the contralateral common carotid artery was ligated, however, more aggregates were found in the ipsi- and contralateral anterior cerebral artery territories (p = 0.01, p = 0.003). Aggregates introduced into the cardiac circulation were equally distributed throughout the brain. This experimental model determined patterns of flow that might be analogous to the human situation where unilateral or bilateral carotid stenosis or stenosis with contralateral occlusion has occurred or embolus from cardiac source has occurred. The results do not imply that the 40 micron microaggregates do cause TIA. These experimental findings support clinical observations that cardiac lesions may cause transient ischemic attacks (TIA) anywhere in the brain. In contrast, those of carotid artery origin cause predominantly middle cerebral or ophthalmic artery territory TIAs unless the contralateral carotid artery is severely stenosed or occluded.This publication has 15 references indexed in Scilit:
- The enigma of the risk of stroke in mitral valve prolapse.Stroke, 1985
- Therapy of Ischemic Cerebral Vascular Disease Due to AtherothrombosisNew England Journal of Medicine, 1984
- POTENTIAL SOURCES OF EMBOLI IN PATIENTS WITH PRESUMED TRANSIENT CEREBRAL OR RETINAL ISCHAEMIAThe Lancet, 1981
- A Randomized Trial of Aspirin and Sulfinpyrazone in Threatened StrokeNew England Journal of Medicine, 1978
- Cerebral MicroembolizationArchives of Neurology, 1978
- Blood flow measurements with radionuclide-labeled particlesProgress in Cardiovascular Diseases, 1977
- Experimental Cerebral EmbolismJournal of Neuropathology and Experimental Neurology, 1959
- The Effect of Different Sized Emboli on the Vascular System and Parenchyma of the BrainJournal of Neuropathology and Experimental Neurology, 1952
- TRANSIENT CEREBRAL PARALYSIS IN HYPERTENSION AND IN CEREBRAL EMBOLISMJAMA, 1948
- Ueber Verstopfung der Blutgefässe des AugesAlbrecht von Graefes Archiv für Ophthalmologie, 1868