Origin of Carcinoma of the Bronchus

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Abstract
A study of 330 cases of bronchial cancer occurring from January 1, 1950, to January 1, 1960, diagnosed by biopsy, cytology, operation, or autopsy revealed: 1) Not every birth year contributed equally to the number of cases; 2) the month of birth was an important factor, with a high peak late in winter (March). This seasonal influence could be explained by the absence of vitamin A at birth, when the lungs begin to function. Lack of vitamin A at that critical time causes an irreversible metaplasia. Later, this tissue cannot cope with the normal stimuli of life and predisposes the individual to various pulmonary diseases, including cancer.

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