epsilon 4 Allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population
- 1 June 1996
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 46 (6) , 1749-1751
- https://doi.org/10.1212/wnl.46.6.1749
Abstract
We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of epsilon 4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi squared = 8.2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese. NEUROLOGY 1996;46: 1749-1751Keywords
This publication has 6 references indexed in Scilit:
- Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's diseaseAnnals of Neurology, 1995
- Basic aspects of neuroimmunology as they relate to immunotherapeutic targets: Present and future prospectsAnnals of Neurology, 1995
- FOREWORDJournal of Neurology, Neurosurgery & Psychiatry, 1994
- Ischaemic preconditioning: can the protection be bottled?The Lancet, 1993
- THIS WEEK IN SCIENCEScience, 1993
- Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and caroteneThe Lancet, 1991