Anaplastic giant and spindle-cell carcinoma of the thyroid. A different therapeutic approach

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Abstract
The prognosis of giant and spindle cell carcinoma of the thyroid is extremely poor. It does appear, however, that a multidisciplinary approach to treatment of this aggressive cancer is more effective than a single-treatment modality. Operative ablation of gross tumor, postoperative irradiation therapy, and chemotherapy have demonstrated encouraging results. A different therapeutic approach with the addition of immunotherapy to surgical resection, postoperative irradiation, and chemotherapy is described in this case report. The preliminary result is encouraging.