Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 62 (1) , 101-102
- https://doi.org/10.1007/bf00426043
Abstract
Previous studies have demonstrated that long-term administration of d-amphetamine produces a progressive augmentation of behavior. In the present experiment, rats receiving repeated systemic injections responded to an intraventricular infusion of d-amphetamine with an augmented increase in locomotor activity. These results indicate that central mechanisms, rather than peripheral dispositional factors, subserve the enhanced behavioral response to repeated amphetamine administration.This publication has 7 references indexed in Scilit:
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