INTOXICATION DUE TO CHLORDANE
- 2 August 1952
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 149 (14) , 1314-1316
- https://doi.org/10.1001/jama.1952.72930310008010e
Abstract
Chlordane is a commonly used insecticide with the empirical formula C10H6Cl8 and the following structural formula. Stohlman, Thorp, and Smith1 have reported that it causes acute toxicity in rabbits equal to that caused by dichlorodiphenyltrichloroethane (DDT), a similar compound, in equivalent oral dosage (L.D.50), and that it causes greater chronic toxicity than does this similar compound because of greater cumulative action. Lehman2 reported that toxicity in rats occurred after 12 weeks' administration of chlordane, 250 parts per million in the diet, the lowest intake causing gross demonstrable defects, whereas the toxic dose of dichlorodiphenyltrichloroethane was only 100 parts per million, but this required administration for 104 weeks. In dogs, administration of chlordane, 660 parts per million, caused death in four weeks; 2,640 parts per million of dichlorodiphenyltrichloroethane was necessary over a similar period. As with dichlorodiphenyltrichloroethane, continuous administration of chlordane to laboratoryKeywords
This publication has 1 reference indexed in Scilit:
- STUDIES IN CIRRHOSIS OF THE LIVER. I. RELATIONSHIP BETWEEN PLASMA VOLUME, PLASMA PROTEIN CONCENTRATIONS AND TOTAL CIRCULATING PROTEINSJournal of Clinical Investigation, 1949