Hide, shield and strike back: how HIV-infected cells avoid immune eradication
- 1 February 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 3 (2) , 97-107
- https://doi.org/10.1038/nri998
Abstract
Viruses that induce chronic infections can evade immune responses. HIV is a prototype of this class of pathogen. Not only does it mutate rapidly and make its surface components difficult to access by neutralizing antibodies, but it also creates cellular hideouts, establishes proviral latency, removes cell-surface receptors and destroys immune effectors to escape eradication. A better understanding of these strategies might lead to new approaches in the fight against AIDS.Keywords
This publication has 138 references indexed in Scilit:
- Intensification and Stimulation Therapy for Human Immunodeficiency Virus Type 1 Reservoirs in Infected Persons Receiving Virally Suppressive Highly Active Antiretroviral TherapyThe Journal of Infectious Diseases, 2002
- HIV-1 Integration in the Human Genome Favors Active Genes and Local HotspotsCell, 2002
- Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population LevelScience, 2002
- Positive Transcription Elongation Factor b Phosphorylates hSPT5 and RNA Polymerase II Carboxyl-terminal Domain Independently of Cyclin-dependent Kinase-activating KinaseJournal of Biological Chemistry, 2001
- Control of Homeostasis of CD8 + Memory T Cells by Opposing CytokinesScience, 2000
- Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 tat-activationJournal of Molecular Biology, 1998
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- Viral dynamics in human immunodeficiency virus type 1 infectionNature, 1995
- Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domainCell, 1994
- HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structureCell, 1990