Studies on the Effect of Aflatoxin B1 on the Development of the Chick Embryo

1 March 1968

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 127 (3) , 835-839
https://doi.org/10.3181/00379727-127-32816

Abstract

Surviving embryos of fertile hens'' eggs injected with an effective dose (approximately LD70) of aflatoxin B1 showed a marked depression in growth only after day 12 of development. Surviving embryos did not show any gross morphological abnormalities. The pattern of development of several enzymes (acid phosphatase, alkaline phosphatase, and GOT [glutamic oxaloacetic transaminase]) in the aflatoxin-treated eggs showed only minor differences from that of the controls. An effective dose (approximately LD70) of aflatoxin B1 does not affect the early stages of differentiation and growth, but does depress growth after day 12 of development.

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