ALOX5AP Gene and the PDE4D Gene in a Central European Population of Stroke Patients
- 1 April 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 36 (4) , 731-736
- https://doi.org/10.1161/01.str.0000157587.59821.87
Abstract
Background and Purpose— Recent evidence has implicated the genes for 5-lipoxygenase activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) as susceptibility genes for stroke in the Icelandic population. The aim of the present study was to explore the role of these genes in a central European population of stroke patients. Methods— A total of 639 consecutive stroke patients and 736 unrelated population-based controls that had been matched for age and sex were examined using a case-control design. Twenty-two single-nucleotide polymorphisms (SNPs) covering ALOX5AP were genotyped. For PDE4D, microsatellite AC008818-1 and 12 SNPs, which tag all common haplotypes in previously identified linkage disequilibrium (LD) blocks, were analyzed. Results— A nominally significant association with stroke was observed with several SNPs from ALOX5AP, including SNP SG13S114, which had been part of the Icelandic at-risk haplotype. Associations were stronger in males than in females, with SG13S114 (odds ratio, 1.24; 95%...Keywords
This publication has 18 references indexed in Scilit:
- The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and strokeNature Genetics, 2004
- The gene encoding phosphodiesterase 4D confers risk of ischemic strokeNature Genetics, 2003
- Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesisProceedings of the National Academy of Sciences, 2003
- Identification of 5-Lipoxygenase as a Major Gene Contributing to Atherosclerosis Susceptibility in MiceCirculation Research, 2002
- Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12American Journal of Human Genetics, 2002
- Phorbol 12-myristate 13-acetate Triggers the Protein Kinase A-Mediated Phosphorylation and Activation of the PDE4D5 cAMP Phosphodiesterase in Human Aortic Smooth Muscle Cells through a Route Involving Extracellular Signal Regulated Kinase (ERK)Molecular Pharmacology, 2001
- Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjectsBritish Journal of Pharmacology, 2001
- Expression of Phosphodiesterase 4D (PDE4D) Is Regulated by Both the Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinase Signaling PathwaysPublished by Elsevier ,2000
- Activation of cAMP–PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injuryNature Medicine, 1997
- Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and InflammationScience, 1983