A-8103 in Polycythemia

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Abstract
COMPOUND 8103-Abbott (A-8103), a neutral amide of piperazine (NSC-25154), 1, 4-bis (3-bromopropronyl) piperazine, was shown to have a favorable effect upon neoplastic disease including polycythemia rubra vera by Bond et al in 1962.1The antitumor properties of the neutral amide were first demonstrated in transplanted adenocarcinoma, Ca 755 in mice, and spontaneous breast adenocarcinoma in rats.2-4Later this agent was shown to be active in chronic granulocytic leukemia and metastatic epithelial malignancies.5,6At present, the mechanism of action for A-8103 is not shown. Its chemical structure suggests that it is an alkylating agent. Hematopoietic suppression was noted during initial Phase I and Phase II studies. Subsequently, Bond and Rohn observed a 94% response in patients with polycythemia vera who were refractory to radioactive phosphorus and alkylating agents.7These favorable preliminary results stimulated the present study by the Midwest Cooperative Chemotherapy Group. Materials and Methods Diagnosis.— The minimum

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