RACIAL DISTRIBUTION OF ALPHA-1-ANTITRYPSIN VARIANTS AMONG JUNIOR HIGH-SCHOOL STUDENTS

Publisher Website
Google Scholar
Abstract
A survey of .alpha.1-antitrypsin phenotypes and serum trypsin inhibitory capacities was performed in 1841 7th grade junior high school students. Antitrypsin deficiency states were detected only in white subjects (3.04%) and not in 461 subjects of other races or of Mexican origin. A screening level of serum trypsin inhibitory capacity at 75% of normal or less included all of the deficient phenotypes, but phenotyping was necessary to eliminate a small percentage of normal and unimportant variant phenotypes from this group. Future programs for detecting antitrypsin deficiency and for counseling students who are genetically prone to develop pulmonary emphysema should be aimed primarily at white populations.

This publication has 0 references indexed in Scilit: