Extended-Spectrum Cephalosporinases: Structure, Detection and Epidemiology
- 24 May 2007
- journal article
- review article
- Published by Taylor & Francis in Future Microbiology
- Vol. 2 (3) , 297-307
- https://doi.org/10.2217/17460913.2.3.297
Abstract
Extended-spectrum AmpC beta-lactamases of Enterobacteriaceae, which are chromosomally or plasmid-encoded, possess structural modifications in the vicinity of the active site compared with their progenitors. They display an increased catalytic efficiency against extended-spectrum beta-lactams, such as ceftazidime, cefotaxime, cefepime, cefpirome and, in some cases, also against imipenem. An overview of the molecular and biochemical characterization of this recently identified mechanism of resistance to beta-lactams is provided as well as its prevalence and possible clinical significance.Keywords
Funding Information
- Ministère de l‘Education Nationale et de la Recherche (UPRES-EA3539)
- European Community
This publication has 34 references indexed in Scilit:
- AmpC β-Lactamase in an Escherichia coli Clinical Isolate Confers Resistance to Expanded-Spectrum CephalosporinsAntimicrobial Agents and Chemotherapy, 2004
- Inhibitor-Sensitive AmpC β-Lactamase Variant Produced by an Escherichia coli Clinical Isolate Resistant to Oxyiminocephalosporins and CephamycinsAntimicrobial Agents and Chemotherapy, 2004
- Resistance to Cefepime and Cefpirome Due to a 4-Amino-Acid Deletion in the Chromosome-Encoded AmpC β-Lactamase of a Serratia marcescens Clinical IsolateAntimicrobial Agents and Chemotherapy, 2004
- Selection during Cefepime Treatment of a New Cephalosporinase Variant with Extended-Spectrum Resistance to Cefepime in an Enterobacter aerogenes Clinical IsolateAntimicrobial Agents and Chemotherapy, 2004
- Plasmid-Determined AmpC-Type β-LactamasesAntimicrobial Agents and Chemotherapy, 2002
- Susceptibility testing with linezolid by different methods, in relation to published 'general breakpoints': J Antimicrob Chemother 2001; 48: 452-454Journal of Antimicrobial Chemotherapy, 2001
- Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase of anEnterobacter cloacaeclinical isolateFEMS Microbiology Letters, 2001
- Analysis of the effects of -42 and -32 ampC promoter mutations in clinical isolates of Escherichia coli hyperproducing AmpCJournal of Antimicrobial Chemotherapy, 2000
- Sequences of Homologous β-Lactamases from Clinical Isolates of Serratia marcescens with Different Substrate SpecificitiesAntimicrobial Agents and Chemotherapy, 1998
- Molecular Evolution of a Class C β-Lactamase Extending Its Substrate SpecificityJournal of Biological Chemistry, 1995