Decreased l‐arginine‐nitric oxide pathway in cultured myoblasts from spontaneously hypertensive versus normotensive Wistar‐Kyoto rats
- 2 September 1996
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 392 (3) , 242-244
- https://doi.org/10.1016/0014-5793(96)00817-4
Abstract
The hypertrophy of the arterial media exhibited by spontaneously hypertensive rats is related to the hyperproliferation of their smooth muscle cells in culture. Using two methods to assay nitric oxide synthase activity, we showed that this abnormal proliferation results from a decreased activity of the inducible NOS II and less modulation of this enzymatic activity by these cells compared to control Wistar Kyoto cells.Keywords
This publication has 17 references indexed in Scilit:
- Expression of nitric oxide synthase by cytokines in vascular smooth muscle cells.Hypertension, 1994
- The vasodilatory effect of endogenous nitric oxide is a major counter-regulatory mechanism in the spontaneously hypertensive ratJournal Of Hypertension, 1993
- Nitric Oxide Synthase Activity in Genetic HypertensionBiochemical and Biophysical Research Communications, 1993
- Nitric Oxide Mediates Interleukin-1-Induced Prostaglandin E2 Production by Vascular Smooth Muscle CellsBiochemical and Biophysical Research Communications, 1993
- OPC-13340, a New Dihydropyridine Calcium Channel Blocker Attenuates Rapid Vascular Smooth Muscle Cell Growth in Spontaneously Hypertensive RatsJournal of Cardiovascular Pharmacology, 1992
- Inducible but not constitutive production of nitric oxide by vascular smooth muscle cellsEuropean Journal of Pharmacology, 1991
- Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.Circulation Research, 1989
- Abnormalities in growth characteristics of aortic smooth muscle cells in spontaneously hypertensive rats.Hypertension, 1989
- Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange.Journal of Clinical Investigation, 1989
- Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophagesBiochemical and Biophysical Research Communications, 1984