Synthesis of a kinetically stable yttrium-90 labelled macrocycle–antibody conjugate

1 January 1989

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 12,p. 797-798
https://doi.org/10.1039/c39890000797

Abstract

Lysine is a precursor for the synthesis of an aminobutyl C-functionalised tetra-azacyclododecane tetra-acid which has been linked to B72.3 antibody and may be labelled with ⁹⁰Y to form a kinetically stable complex of potential use in radioimmunotherapy.

Keywords

ANTIBODY
YTTRIUM
MACROCYCLE
KINETICALLY STABLE
FUNCTIONALISED
CONJUGATE
AMINOBUTYL
LYSINE
B72.3
90Y