No Rebound of Morbidity Following Intermittent Preventive Sulfadoxine‐Pyrimethamine Treatment of Malaria in Infants in Gabon
Open Access
- 1 December 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 200 (11) , 1658-1661
- https://doi.org/10.1086/647990
Abstract
In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18–30 months were followed up after having received their last dose at an age of 15 months. In the intention-to-treat population, the protective efficacy against all malaria episodes was −18.0 (95% confidence interval, −97.4 to 29.5; P=.529). The protective efficacy against first or only anemia episode was −45.3 (95% confidence interval, −234.5 to 36.3; P=.375). The protective efficacies were negative and were not statistically significant. These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants Clinical trials registrationNCT00167843Keywords
This publication has 0 references indexed in Scilit: