Integral Coefficients of Multi-Compartment Pharmacokinetic Models

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Abstract
An evaluation is made of the various constants and parameters of multiple-compartment pharmacokinetic models concerning their pertinence to chemotherapy. Drug level-time areas best reflect the availability of drug to various pharmacologic sites or body compartments and can be reduced to simple dose-independent integral coefficients. These, in turn, can serve to summarize and partly replace ambiguous transfer and elimination rate constants normally reported for pharmacokinetic data. The value of this procedure is demonstrated by the ranking of the total non-protein bound body levels of a series of penicillin derivatives using data reported for a 2-compartment open model.

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