Precurarisation in infants and children less than three years of age
- 1 January 1987
- journal article
- research article
- Published by Springer Nature in Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Vol. 34 (1) , 17-20
- https://doi.org/10.1007/bf03007676
Abstract
Sixty patients less than three years of age about to undergo adenoidectomy or endoscopy were divided into three groups of 20 each according to age (0-11 months, 12-23 months, 24-35 months). Before the induction of anaesthesia with thiopentone, either tubocurarine 0.05 mg.kg-1 or normal saline was given at random in a double-blind fashion. Three minutes later, the children received succinylcholine 1.5 or 1 .Omg.kg-1, respectively. Muscle movements were graded according to a four-point scale. Blood was sampled for creatine kinase (CK) activity before anaesthesia and on the following morning. When all age groups were combined, there was a significant reduction of muscle movements in patients who had received tubocurarine pretreatment. Serum CK activity rose significantly when saline pretreatment was used in children over the age of one year but not in the infants, despite the presence of muscle movements following succinylcholine administration. Soixante patients tous âgés de moins de trois ans et devant subir une adénoidectomie ou une endoscopie, ont été divisés selon ľâge en trois groupes de 20. Avant ľinduction de ľanesthésie avec thiopentone, soit de la DTC 0.05 mg-kg-1 ou du salin physiologique a été administré au hasard et à double insu. Trois minutes plus tard les enfants ont reçu respectivement de la succinylcholine 1.5 ou 1.0 mg-kg-1. Les mouvements musculaires ont été gradés ďaprès une échelle à quatre points. Du sang a été retiré pour ľactivité de la creatinine kinase (CK) avant ľanesthésie et le lendemain matin. Quand tous les groupes ont été combinés on a noté une diminution significative des mouvements musculaires avec le pré-traitement à la DTC. Ľactivité sérique de la CK s’éleva significativement quand le pré-traitement au salin physiologique était utilisé pour les enfants dont ľâge est supérieur à un an et non chez ceux âgés de moins ďun an malgré les fasciculations musculaires.Keywords
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