ON THE MODE OF ACTION OF IODOTHIOURACIL
- 1 February 1954
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 14 (2) , 232-241
- https://doi.org/10.1210/jcem-14-2-232
Abstract
Admn. to rats of iodothiouracil, mixed in the diet, 1% or 3% concn., after 10 days resulted in more than 2-fold thyroid enlargement, increased thyroid vascularity, increased cell height, discharge of colloid, and a many-fold increase in the iodide space. The iodide-accumulating mechanism was flooded by iodothiouracil. Observations were interpreted as indicating that iodothiouracil acts in the rat to increase thyrotropic hormone elaboration and thus to result in goiter formation; no support for the concept that iodothiouracil has a unique mode of action was found in this study.Keywords
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