SEROLOGICAL FACTORS AS POSSIBLE CAUSES IN SPONTANEOUS ABORTIONS*

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Abstract
It is now established that a specific disease of the fetus and the new-born, erythroblastis fetalis, can be attributed not to disease in the father or in the mother, but rather to genetic and constitutional differences in the antigenic composition of their erythrocytes. The actual mechanism depends upon isoimmunization of the mother by the Rh factor in fetal blood and the intra-uterine action of maternal anti-Rh agglutinins on susceptible fetal blood. Evidence of a preliminary nature is presented to indicate that the same mechanism induced by other blood factors may be responsible for both early and late fetal death, i.e., abortions and stillbirths.