Aspects of successful drug discovery and development
- 8 June 2006
- journal article
- review article
- Published by Elsevier in Antiviral Research
- Vol. 71 (2-3) , 77-89
- https://doi.org/10.1016/j.antiviral.2006.05.007
Abstract
No abstract availableKeywords
This publication has 50 references indexed in Scilit:
- TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1Antimicrobial Agents and Chemotherapy, 2004
- Peptide inhibitors of virus—cell fusion: enfuvirtide as a case study in clinical discovery and developmentThe Lancet Infectious Diseases, 2004
- Current Status of the Non-nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1Current Topics in Medicinal Chemistry, 2004
- Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 VariantsJournal of Medicinal Chemistry, 2004
- Transmission Fitness of Drug‐Resistant Human Immunodeficiency Virus and the Prevalence of Resistance in the Antiretroviral‐Treated PopulationThe Journal of Infectious Diseases, 2003
- Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant MutantJournal of Molecular Biology, 1996
- Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100Antimicrobial Agents and Chemotherapy, 1994
- Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurineAntimicrobial Agents and Chemotherapy, 1993
- Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.Proceedings of the National Academy of Sciences, 1992
- Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitroBiochemical and Biophysical Research Communications, 1987