Common Duct Carcinoma and Obstruction in Female Hamsters Treated with N-Nitrosobis(2-oxopropy1)amine and/or Cholecystectomy
- 1 November 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Pancreas
- Vol. 2 (6) , 688-693
- https://doi.org/10.1097/00006676-198711000-00011
Abstract
Detailed histologic observations were performed on the head of the pancreas of hamsters treated with 10 mg/kg body weight N-nitrosobis(2-oxopropyl)amine (BOP) once a week for 6 weeks with or without cholecystectomy. Cholecystectomy was performed 5 weeks before starting BOP initiation. The incidence of head cancers was 100% and cholecystectomy did not affect pancreatic carcinogenesis by BOP. Common bile duct dilatation was produced by advanced pancreatic head carcinomas and microadenocarcinomas in common duct. Micro-adenocarcinomas were not macroscopically detected since the tumors were located in the lumen of common duct.Keywords
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