Selective A3 adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system
- 1 September 2008
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 16 (18) , 8546-8556
- https://doi.org/10.1016/j.bmc.2008.08.007
Abstract
No abstract availableKeywords
This publication has 37 references indexed in Scilit:
- Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor LigandsNucleosides, Nucleotides and Nucleic Acids, 2008
- Three-Dimensional Quantitative Structure−Activity Relationship of Nucleosides Acting at the A3Adenosine Receptor: Analysis of Binding and Relative EfficacyJournal of Chemical Information and Modeling, 2007
- Adenosine receptors as therapeutic targetsNature Reviews Drug Discovery, 2006
- Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5′-ribofuran-uronamide moietyBioorganic & Medicinal Chemistry Letters, 2006
- “Reversine” and Its 2-Substituted Adenine Derivatives as Potent and Selective A3 Adenosine Receptor AntagonistsJournal of Medicinal Chemistry, 2005
- (N)-Methanocarba 2,N6-Disubstituted Adenine Nucleosides as Highly Potent and Selective A3 Adenosine Receptor AgonistsJournal of Medicinal Chemistry, 2004
- Construction of a cis-Cyclopropane via Reductive Radical Decarboxylation. Enantioselective Synthesis of cis- and trans-1-Arylpiperazyl-2-phenylcyclopropanes Designed as Antidopaminergic AgentsThe Journal of Organic Chemistry, 2003
- Radiolabeling and efficient synthesis of tritiated 2-chloro-N6-(3-iodobenzyl)adenosine-5′-N-methyluron-amide, a potent, selective A3 adenosine receptor agonistJournal of Labelled Compounds and Radiopharmaceuticals, 1996
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973