Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury

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Abstract
Neutrophil recruitment is one of the hallmarks of acute inflammation. A potent neutrophil chemotactic and activating factor, interleukin‐8 (IL‐8), has been demonstrated to be elevated in body fluids in various human diseases and experimental animal models. Recent investigations on animal disease models using blocking antibodies to IL‐8 have revealed the essential involvement of IL‐8 in acute inflammation. We previously reported that the administration of a neutralizing antibody against IL‐8 prevented the neutrophil infiltration and neutrophil‐mediated tissue injury in several animal studies. In addition, we have recently demonstrated that anti‐IL‐8 treatment is also effective in prevention of two models that are very relevant to clinical situations: cerebral reperfusion injury and endotoxemia‐induced acute respiratory distress syndrome‐like lung injury. These results further support the hypothesis that IL‐8 has a pivotal role and is a novel target for therapeutic intervention in neutrophil‐mediated injury. J. Leukoc. Biol.62: 581–587; 1997.

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