The metabolism of cyclophosphamide. Dose dependency and the effect of long-term treatment with cyclophosphamide

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Abstract
Studies on the metabolism of cyclophosphamide-14C were performed in 10 subjects at different single dose levels within the range of 0.02–10 mg/kg body-weight and in five subjects before and following an average 22 days treatment with cyclophosphamide in daily doses of 2 mg/kg. The parameters of cyclo-phosphamide metabolism—serum half-life of unchanged cyclophosphamide, serum concentration of metabolites, and rates of excretion of cyclophosphamide and metabolites in the urine—were all independent of dose. No change of the metabolism was demonstrated after treatment with cyclophosphamide for 22 days.