Transient Thyrotoxicosis in an Infant Delivered to a Long-Acting Thyroid Stimulator (LATS)- and LATS Protector-Negative, Thyroid-Stimulating Antibody- Positive Woman with Hashimoto’s Thyroiditis*

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Abstract
A thyrotoxic infant was delivered to a womanwith a long-standing history of Hashimoto’s thyroiditis, but withno evidence of Graves’ disease. Long-acting thyroid stimulator(LATS) and LATS protector were absent, but thyroid-stimulatingantibody was transiently present in the infant and markedlyand persistently elevated in the mother. It is concluded that the maternal level of thyroid-stimulating immunoglobulins determinesthe presence and duration of transient neonatal thyrotoxicosis,and that thyroid-stimulating antibody is distinct fromLATS and LATS protector.

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