THE EFFECTS OF THE ADRENAL CORTEX ON THE RELEASE OF N15FROM TISSUE PROTEINS OF RATS PREVIOUSLY FED N15-GLYCINE

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Abstract
SEVERAL recent investigations (White et al., 1948; Hoberman, 1953; Clark, 1953; Parson et al., 1952) have been concerned with the effects of the adrenal cortex on the incorporation of N15-glycine into tissue proteins under various conditions, from which attempts have been made to assign to the C11-oxysteroids the role of increasing catabolism, decreasing anabolism, or both. These experiments were all designed in such a way that the endocrine excess or deficiency existed prior to or concomitant with the administration of labeled glycine. The possibility therefore existed that the observed results were secondary to the metabolic state previously established by the endocrine disturbance, namely an increased net mobilization of endogenous foodstuff from the periphery in the case of cortisonetreated animals (Wells, 1940; Wells and Kendall, 1940; Silber and Porter, 1953); or a decreased net mobilization in the case of adrenalectomized animals (Wells and Kendall, 1940). Probably the prior existence of either general state, i.e., a positive or negative nitrogen balance, would alter the manner in which additional exogenous substrate is metabolized (Handler, 1952).

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