Brain and Eye Abnormalities

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Abstract
An infant with multiple eye and central nervous system (CNS) deformities was born to a 19-year-old mother who smoked marihuana and took multiple drugs, including lysergic acid diethylamide (LSD), throughout pregnancy. The baby made no developmental progress and required gavage feedings throughout life. A ventriculojugular shunt was inserted when the infant was 4 months of age because of progressive hydrocephalus, and the infant died at 13 months of age. Multiple malformations of the cerebrum and cerebellum and aqueductal stenosis were found at autopsy. Ocular abnormalities similar to those induced in mice following LSD administration were present.