Trisomy 21 with 47,+18 lymphocyte cell line: double mitotic nondisjunction.
- 1 October 1978
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 15 (5) , 395-398
- https://doi.org/10.1136/jmg.15.5.395
Abstract
A patient with Down''s syndrome had 47,XX,+18/47,XX,+21 mosaicism. Chromosome 18 trisomy was found only in 18% of lymphocytes and not in skin fibroblasts. A likely interpretation is double nondisjunction in a single lymphocyte precursor of a trisomy 21 embryo. A brief review of other cases of mitotic multiple nondisjunction and double aneuploid mosaicism is presented.Keywords
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