EFFECT OF DENGUE VIRUS-INDUCED CYTO-TOXIC FACTOR ON FC-RECEPTOR FUNCTIONS OF MOUSE MACROPHAGES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 65  (1) , 11-17
Abstract
Whether alterations in Fc-mediated functions of macrophages in DV[dengue type 2 virus]-infected mice are due to a virus-induced cytotoxic factor [CF] was studied. Mice given CF i.v. showed a rapid fall in total numbers of peritoneal and spleen cells. The number of cells in the peritoneal cavity recovered in 48 h; recovery in the spleen was not significant. The capacity of the splenic and peritoneal macrophages to attach and ingest opsonized sheep erythrocytes was significantly reduced, the lowest values of attachment index (AI) and phagocytic index (PI) being observed within 2-3 h. At later periods the AI values increased markedly but the PI values remained depressed. The effect was dose-dependent. The effect on Fc-receptor functions of macrophages in DV-infected mice thus appears to be mediated through CF.