EFFECT OF MICROBIAL FRACTIONS ON THE METABOLISM OF LIVER AND MONOCYTES FROM MICE

Abstract
Soluble and particulate fractions of sonically treated Pseudomonas aeruginosa depressed the succinoxidase activity of both liver preparations and monocytes from mice. Bacterial extracts appeared more toxic than intact organisms. Inhibition of oxidase activity was proportional to the concentration of bacterial extract. Lipopolysaccharide endotoxins of various organisms other than the pseudomonads did not affect either oxidase activity or glycolysis in mouse monocytes.