THE RÔLE OF COLLOID AND OF SALINE IN THE TREATMENT OF SHOCK 12

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Abstract
In early salt depletion shock replacement of the salt deficits by either 0.9% or 5% saline was followed by restoration of the plasma vol., the circulating plasma protein, and the circulatory dynamics to normal limits. An identical degree of recovery, however, was observed following admn. of small amts. of either serum or gelatin containing only sufficient salt to replace 11-36% of the initial deficits. Admn. of small amts. of either low salt colloid solns., or of 0.9% saline in amts. equivalent to only 17-43% of the initial deficit, failed to improve the circulatory status beyond the degree observed to occur spontaneously in untreated animals. Colloid-containing solns. can exert a beneficial effect on the circulation in salt depletion shock clearly beyond that due to the NaCl which they contain. Optimal therapy of all forms of shock should include not only the replacement of salt deficits present, but also the admn. of colloid-containing solns.