Enhanced Effect of Cyclophosphamide on Burkitt Lymphoma Cell Lines in Vivo

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Abstract
Summary Cells from three Burkitt lym-phoma lines and three normal-derived human lymphoid lines were cultured in diffusion chambers implanted into mice. Cytoge-netic analysis was made on all these cell lines following treatment of the animals with cyclophosphamide. The Burkitt lymphoma cell lines were uniformly more sensitive to cyclophosphamide than the normal-derived cell lines, having a chromosome aberration incidence of 58-82% compared to 14-23% for the latter cell lines. Studies in tissue culture failed to reveal either the cytostatic effect of cyclophosphamide or an effect on chromosomes.