The Fetal Uptake of Cerium-144-praseodymium-144 after Injection of Its Chelates to Pregnant Rat

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Abstract
On the 17th day of pregnancy albino rats were injected intravenously with 144Ce 144Pr chloride, citrate, nitrilotriacetate (NTA), or ethylenediaminetetraacetate (EDTA) and sacrificed at intervals up to 4 days later. The radioactivity of fetuses, placentae, amniotic fluid, maternal blood and maternal femora was measured. Deposition of the four 144Ce compounds in the fetuses was small: the greatest deposition, 0,013 % of the injected dose deposited in one fetus, was observed 4 days after injection of 144CeEDTA. The radioactivity of the fetuses generally increased with time after injection of 144CeCls or 144CeEDTA. Deposition of 144Ce in the fetuses was greatest after injection of 144CeEDTA or 144Ce-citrate and least after injection of 144CeCl3 or 144CeNTA, but the differences were not always significant. Deposition of 144Ce in the placenta was greatest after injection of 144CeEDTA. Deposition of 144Ce in maternal bone was significantly greater after injection of 144Ce chelates than after injection of 144CeCl3.

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