Cases of multicentric gliomas of similar morphology have been well documented, but the simultaneous occurrence of a glioblastoma multiforme and a distinctly separate astrocytoma has been rarely recognized and inadequately described. Both a glioblastoma multiforme and a cystic piloid astrocytoma (spongioblastoma polare) were observed at autopsy in a 62-year-old woman thought to have an occult malignancy with multiple metastatic intracranial neoplasms. This case supports the occurrence of multicentric gliomas on the basis of the development of multiple primary foci, which has been illustrated previously by experiments in animals.