Normal levels of serum glycoproteins maintained in β‐1,4‐galactosyltransferase I‐knockout mice
- 20 December 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 464 (1-2) , 75-79
- https://doi.org/10.1016/s0014-5793(99)01681-6
Abstract
The galactose-mediated clearance of serum glycoproteins from the circulation was evaluated using β-1,4-galactosyltransferase (β-1,4-GalT) I-knockout mice. Partial structural study of the oligosaccharides released from mouse serum glycoproteins revealed that 77.4% of the oligosaccharides from β-1,4-GalT I+/+ mouse contain galactose, while 7.7% of those from β-1,4-GalT I−/− mouse were galactosylated. Under the conditions, no significant change in serum protein concentrations was observed between the normal and mutant mice. The results indicate that the hepatic asialoglycoprotein receptor-mediated system is not functioning in the clearance of endogenous serum glycoproteins.Keywords
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