Increased Phagocytosis of Escherichia coli Pretreated with Subinhibitory Concentrations of Cyclacillin or Ampicillin

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Abstract
When incubated with subinhibitory concentrations of cyclacillin or ampicillin E. coli became more susceptible to subsequent phagocytosis by normal mouse monocytes (peritoneal exudate cells). Incubation for as little as 1 h markedly increased the phagocytosis, which in turn was associated with increased intracellular killing of antibiotic-treated bacteria. Regardless of the length of time of incubation of the penicillin-resistant E. coli with K penicillin G there was no significant increase in phagocytosis.

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