THE ANTIMITOTIC AND CARCINOSTATIC ACTION OF OVARIAN EXTRACTS
Open Access
- 1 August 1957
- journal article
- research article
- Published by University of Chicago Press in The Biological Bulletin
- Vol. 113 (1) , 129-134
- https://doi.org/10.2307/1538807
Abstract
Extracts of the ovaries of cows, pigs and sheep can suppress mitosis in eggs of the worm Chaetopterus. This they do by keeping the protoplasm fluid and inhibiting the mitotic gelation which is a necessary precursor of the mitotic spindle. The potent substance or substances in extracts of cow ovaries can be precipitated by treating the extracts in the cold with intermediate concentrations of alcohol. Such purified preparations have a definite antimitotic effect and they also have a very definite carcinostatic action.This publication has 3 references indexed in Scilit:
- ANTIMITOTIC SUBSTANCES FROM OVARIESThe Biological Bulletin, 1954
- FERTILIZATION AND ARTIFICIAL ACTIVATION IN THE EGG OF THE SURF-CLAM, SPISULA SOLIDISSIMAThe Biological Bulletin, 1953
- The Action of Tissue Extracts on Cell Division2JNCI Journal of the National Cancer Institute, 1951