Dorsal Pedal Venous Oximetry for Assessing Treatment of Chronic Venous Insufficiency: Effects of Daflon 500 mg

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Abstract
Daflon 500 mg has been shown to have beneficial effects on microcirculatory disturbances causing tissue hypoxia in chronic venous insufficiency (CVI). To assess the effects of Daflon 500 mg on venous disorder in the lower extremity by means of dorsal pedal venous oximetry measurements, a 4-week prospective study was carried out in 33 patients having a mild or moderate stage of CVI in one leg. In treatment with Daflon 500 mg at a daily dose of two tablets, there were significant (p>0.05) increases in partial pressure of oxygen (Po2), oxygen saturation (So2) and pH, and a decrease in partial carbon dioxide pressure (Pco2). Clinical findings attributable to CVI were markedly improved. Comparison of dorsal pedal venous, oximetry parameters in the symptomatic leg and the clinically unaffected other leg was made before and after 4 weeks of oral therapy. Significant (p>0.05) differences were observed between involved and healthy lower limbs.