Macromolecular Prodrugs of Metronidazole. 1. Esterification of Hydroxyl Containing Polymers With Metronidazole Monosuccinate
- 1 January 1985
- journal article
- research article
- Published by Wiley in Bulletin des Sociétés Chimiques Belges
- Vol. 94 (8) , 591-596
- https://doi.org/10.1002/bscb.19850940807
Abstract
Metronidazole was converted into the corresponding monosuccinate ester by treatment with succinic anhydride in almost quantitative yield and under mild reaction conditions. The monosuccinate derivative was subsequently coupled onto dextran, inulin and poly‐[N‐(2‐hydroxyethyl)aspartamide].Keywords
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