Iron and microbial infection
Top Cited Papers
- 1 December 2004
- journal article
- review article
- Published by Springer Nature in Nature Reviews Microbiology
- Vol. 2 (12) , 946-953
- https://doi.org/10.1038/nrmicro1046
Abstract
The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. It is also a pivotal component of the innate immune response through its role in the generation of toxic oxygen and nitrogen intermediates. During evolution, the shared requirement of micro- and macroorganisms for this important nutrient has shaped the pathogen–host relationship. Here, we discuss how pathogens compete with the host for iron, and also how the host uses iron to counteract this threat.Keywords
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