Novel Molecules That Antagonize Leukotriene B4 Binding to Neutrophils
- 1 April 1988
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 524 (1) , 196-200
- https://doi.org/10.1111/j.1749-6632.1988.tb38542.x
Abstract
A series of LTB4 analogues have been synthesized that replace carbons 7–9 of the cis‐trans‐trans triene unit of LTB4 with a stable ring structure. Meta‐substituted pyridine analogues are more potent inhibitors than benzene or furan analogues. C‐1 alcohols are often more potent inhibitors than free carboxylic acids, and 5,6‐cis double bond compounds are more potent than 5,6‐trans compounds. Compounds such as these may prove to be useful in the treatment of inflammatory diseases.Keywords
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