Amantadine: Neuromuscular Blockade by Suppression of Ionic Conductance of the Acetylcholine Receptor
- 17 February 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4330) , 788-790
- https://doi.org/10.1126/science.622570
Abstract
Amantadine hydrochloride decreases the sensitivity of denervated mammalian muscle to iontophoretically applied acetylcholine. The drug depresses the amplitude of the end-plate current and reverses the slope of the relation between half-decay time and membrane potential suggesting that it alters the ionic conductance that is mediated by the acetylcholine receptor. Binding studies confirm that amantadine acts on the ion conductance modulator rather than the acetylcholine receptor.This publication has 19 references indexed in Scilit:
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