Relative conformational rigidity in oxytocin and (1-penicillamine)-oxytocin: a proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism.
- 1 April 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (4) , 1373-1377
- https://doi.org/10.1073/pnas.74.4.1373
Abstract
A comparative study of the PMR and 13C NMR spectral parameters of the peptide hormone oxytocin and of its competitive inhibitor [1-L-penicillamine]oxytocin was made and the results analyzed in terms of comparative conformational and dynamic properties. Oxytocin apparently has a flexible conformation, while [1-L-penicillamine]oxytocin probably has a more restricted conformation. The results provide a framework for understanding the mechanism of peptide hormone agonism and antagonism for these compounds, and an approach for understanding some features of the interaction of the hormone and related compounds with their receptor.Keywords
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