Ultraviolet B irradiation increases endothelin‐1 and endothelin receptor expression in cultured human keratinocytes
- 4 September 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 371 (2) , 188-190
- https://doi.org/10.1016/0014-5793(95)00912-s
Abstract
The effect of ultraviolet B (UVB) irradiation on endothelin-1 (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/105 cells. UVB irradiation up to 10 mJ/cm2 increased ET-1 secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ETA and ETB receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm2 UVB irradiation.Keywords
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