Retinoic acid analogs. Synthesis and potential as cancer chemopreventive agents

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Abstract
Analogs of retinoic acid were synthesized as potential chemopreventive agents against epithelial cancer. Ethyl (E)-9-(2-norbornenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate, (E)-3,7-dimethyl-9-(2-ethyl-6,6-dimethyl-1-cyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid and 2-(2''-methoxyethoxy)ethyl retinoate displayed good activity in the inhibition of tumor promoter[12-O-tetradecanoyl phorbol-13-acetate]-induced mouse epidermal ornithine decarboxylase assay. (E)-1-(3-acetoxyphenyl)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)hexa-1,3,5-triene had low activity. (E)-5-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)octa-1,3,5,7-tetraen-1-yl]tetrazole was inactive.