Clinical Trials in Pediatric Traumatic Brain Injury: Unique Challenges and Potential Responses

1 August 2006

journal article
research article
Published by S. Karger AG in Developmental Neuroscience

Vol. 28 (4-5) , 276-290
https://doi.org/10.1159/000094154

Abstract

In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society.

Keywords

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