Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1.ALPHA., thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats.
- 1 January 1980
- journal article
- research article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 26 (4) , 343-347
- https://doi.org/10.3177/jnsv.26.343
Abstract
Endogenous biosynthetic capacities for prostaglandin (PG)E2, thromboxane (TX)B2 (a stable degradation product of TXA2) and 6 keto-PGF1.alpha. (a stable degradation product of PGI2) in the brainstem fractions of stroke-resistant spontaneously hypertensive rats (SHRSR) and control Wistar-Kyoto rats (WKR) were determined with novel methods and presented in an original report. Compared with WKR, TXB2 synthesis is increased > 3-fold in the pons-medulla oblongata of SHRSR, while being decreased by 75% in the hypothalamic region of SHRSR (0.01 < P < 0.05). The biosynthesis of PGE2 is adaptively elevated in hypothalamus and pons-medulla oblongata regions of each animal, although the PGI2/PGE2 ratio was lowered in both regions of SHRSR.This publication has 0 references indexed in Scilit: