Change in plasma immunoreactive atrial natriuretic peptide during sequential ultrafiltration and haemodialysis

Publisher Website
Google Scholar
Abstract
1. Plasma immunoreactive human atrial natriuretic peptide (Ir-ANP) levels were measured in eight patients with chronic renal failure who were volume-expanded and during treatment by sequential ultrafiltration and haemodialysis. One patient was studied at two separate treatment sessions. 2. Plasma Ir-ANP levels were raised in all patients (mean .+-. SE 184 .+-. 44 pmol/l, n = 9) compared with healthy controls (11 .+-. 1.4 pmol/l), but showed considerable inter-patient variability. 3. Plasma Ir-ANP levels fell with fluid removal during ultrafiltration (123 .+-. 30 pmol/l, n = 9, P < 0.02) and again as fluid was removed during haemodialysis (76 .+-. 20 pmol/l, n = 9, P < 0.02). 4. Seven patients studied 48 h later, before their next dialysis treatment, had regained weight and showed a coincident rise in circulating plasma Ir-ANP (130 .+-. 33 pmol/l, n = 7). 5. Our data would support the hypothesis that the secretion of ANP is determined by volume or by a stimulus related to volume. However, it does not exclude the possibility that a factor other than extracellular fluid volume expansion contributes to the raised plasma Ir-ANP levels in chronic renal failure.