Macromolecular Prodrugs. XVI. Colon-Targeted Delivery—Comparison of the Rate of Release of Naproxen from Dextran Ester Prodrugs in Homogenates of Various Segments of the Pig Gastrointestinal (GI) Tract
- 1 January 1989
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 06 (12) , 995-999
- https://doi.org/10.1023/a:1015914101233
Abstract
We have determined initial rates of naproxen formation from dextran-naproxen ester prodrugs incubated in homogenates of various segments of the pig GI tract. Drug liberation proceeded 15–17 times...Keywords
This publication has 9 references indexed in Scilit:
- Macromolecular prodrugs. XIV. Absorption characteristics of naproxen after oral administration of a dextran T-70-naproxen ester prodrug in pigsInternational Journal of Pharmaceutics, 1989
- Macromolecular Prodrugs. XV. Colon-Targeted Delivery—Bioavailability of Naproxen from Orally Administered Dextran–Naproxen Ester Prodrugs Varying in Molecular Size in the PigPharmaceutical Research, 1989
- Characterization of Dextran Glucosidase (1,6-a-D-Glucan Glucohydrolase) of Streptococcus mitisCaries Research, 1981
- Degradation of polysaccharides by endo‐ and exoenzymes: Dextran–dextranase model systemsBiotechnology & Bioengineering, 1977
- Metabolism of foreign compounds by gastrointestinal microorganisms.1973
- The synthesis of cross-linked dextran and its enzymatic hydrolysisCellular and Molecular Life Sciences, 1971
- Metabolism of Orally Administered Dextran and ‘Sephadex’ Derivatives in the RatNature, 1967
- Observations on the flora of the alimentary tract of animals and factors affecting its compositionThe Journal of Pathology and Bacteriology, 1965