Old Mice: Marrow Response to Bleeding or Endotoxin

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Abstract
Peripheral blood Hb, white cell and lymphocyte levels decreased significantly with age in healthy female B6D2F1 mice. These old mice maintained their Hb levels in the face of chronic blood loss as well as did young mice by releasing younger than normal red blood cells into the peripheral circulation. Before and after bleeding, the old mice had at least as many marrow and spleen CFU-S [colony forming unit, spleen] and CFU-C [colony forming unit, culture (granulocyte/macrophage)] as did young mice. Old mice given endotoxin responded with greater elevations of peripheral blood lymphocytes and polymorphonuclear cell than did young animals; the response of marrow CFU-S, CFU-C and T cell precursors to endotoxin was not impaired in old mice. Evidently, acute bleeding may increase the number of spleen CFU-S and T cell precursors in old animals.

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